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Cadherin2/4-signaling via PTP1B and catenins is critical for nucleokinesis during radial neuronal migration in the neocortex

Martinez Garay, Isabel, Gil-Sanz, Cristina, Franco, Santos J, Espinosa, Ana, Molnár, Zoltan and Mueller, Ulrich 2016. Cadherin2/4-signaling via PTP1B and catenins is critical for nucleokinesis during radial neuronal migration in the neocortex. Development 143 , pp. 2121-2134. 10.1242/dev.132456

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Abstract

Cadherins are crucial for the radial migration of excitatory projection neurons into the developing neocortical wall. However, the specific cadherins and the signaling pathways that regulate radial migration are not well understood. Here, we show that cadherin 2 (CDH2) and CDH4 cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and α- and β-catenins. Surprisingly, perturbation of cadherin-mediated signaling does not affect the formation and extension of leading processes of migrating neocortical neurons. Instead, movement of the cell body and nucleus (nucleokinesis) is disrupted. This defect is partially rescued by overexpression of LIS1, a microtubule-associated protein that has previously been shown to regulate nucleokinesis. Taken together, our findings indicate that cadherin-mediated signaling to the cytoskeleton is crucial for nucleokinesis of neocortical projection neurons during their radial migration.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Company of Biologists
ISSN: 0950-1991
Funders: Wellcome Trust
Date of First Compliant Deposit: 6 May 2016
Date of Acceptance: 26 April 2016
Last Modified: 21 Nov 2018 14:27
URI: http://orca.cf.ac.uk/id/eprint/90592

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