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Coronary artery-bypass-graft surgery increases the plasma concentration of exosomes carrying a cargo of cardiac microRNAs: an example of exosome trafficking out of the human heart with potential for cardiac biomarker discovery

Emanueli, Costanza, Shearn, Andrew I. U., Laftah, Abas, Fiorentino, Francesca, Reeves, Barnaby C., Beltrami, Cristina, Mumford, Andrew, Clayton, Aled, Gurney, Mark, Shantikumar, Saran and Angelini, Gianni D. 2016. Coronary artery-bypass-graft surgery increases the plasma concentration of exosomes carrying a cargo of cardiac microRNAs: an example of exosome trafficking out of the human heart with potential for cardiac biomarker discovery. PLoS ONE 11 (4) , e0154274. 10.1371/journal.pone.0154274

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Abstract

Exosome nanoparticles carry a composite cargo, including microRNAs (miRs). Cultured cardiovascular cells release miR-containing exosomes. The exosomal trafficking of miRNAs from the heart is largely unexplored. Working on clinical samples from coronary-artery by-pass graft (CABG) surgery, we investigated if: 1) exosomes containing cardiac miRs and hence putatively released by cardiac cells increase in the circulation after surgery; 2) circulating exosomes and exosomal cardiac miRs correlate with cardiac troponin (cTn), the current “gold standard” surrogate biomarker of myocardial damage.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Uncontrolled Keywords: CABG, coronary artery-by-pass graft surgery; CPB, cardiopulmonary by-pass; cTn, cardiac troponin; cTn-I, cardiac troponin I; EV, extracellular vesicle; MI, myocardial infarct; miR, microRNA
Publisher: Public Library of Science
ISSN: 1932-6203
Funders: British Heart Foundation
Date of First Compliant Deposit: 13 May 2016
Date of Acceptance: 10 April 2016
Last Modified: 23 Jun 2019 22:08
URI: http://orca.cf.ac.uk/id/eprint/90769

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