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The impact of acute kidney injury in diabetes mellitus

Johnson, Faye, Phillips, Dafydd, Talabani, Bnar, Wonnacott, Alexa, Meran, Soma and Phillips, Aled 2015. The impact of acute kidney injury in diabetes mellitus. Journal of Thrombosis and Haemostatis 21 (6) , pp. 506-511. 10.1111/nep.12649

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Abstract

Little data exist on outcome of Acute Kidney Injury (AKI) in Diabetes. We describe short-term recovery of renal function, patient mortality and progressive renal dysfunction following AKI in diabetics. METHODS: Using the diagnosis of either diabetes or no diabetes as the defining variable, AKI episodes were identified from records of a clinical biochemsitry department serving a population of 560,000. Patient co-morbidity and mortality were collated from electronic patient records. Outcomes were compared to a non-diabetic cohort with AKI. RESULTS: AKI was identified in 101 diabetic and 392 non-diabetic patients. Patients with Diabetes had less severe AKI, compared to the non-diabetic cohort (AKI stage 1 76% vs 55%, p = 0.0006). Overall acute mortality, and mortality adjusted for co-morbidity, was comparable in the diabetic and non-diabetic groups. Recovery to baseline renal function was greater in diabetic patients (87% vs 63% p = 0.001), and the proportion of patients developing progressive CKD was lower in the (14%) compared to the non-diabetic cohort (48%, p < 0.00001). CONCLUSIONS: Although acute mortality is comparable following an AKI episode in diabetics compared to that associated with AKI in a non-diabetic cohort, for those surviving the acute episode its impact on renal function is significantly less than in a non-diabetic group.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Subjects: R Medicine > RZ Other systems of medicine
Publisher: Wiley-Blackwell
ISSN: 1538-7933
Date of Acceptance: 7 October 2015
Last Modified: 26 Nov 2017 03:39
URI: http://orca.cf.ac.uk/id/eprint/90879

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