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1H magnetic resonance spectroscopy of γ-aminobutyric acid: methodological development and multimodal application

Mikkelsen, Mark 2016. 1H magnetic resonance spectroscopy of γ-aminobutyric acid: methodological development and multimodal application. PhD Thesis, Cardiff University.
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Abstract

The topic of this doctoral thesis is the magnetic resonance spectroscopy (MRS) of the neurotransmitter γ-aminobutyric acid (GABA). Its scope encompasses areas of MRS of GABA that currently require material methodological improvement and further empirical investigation. Thus, the work presented herein has two overarching objectives. Firstly, to develop MRS of GABA by addressing outstanding methodological limitations of the technique, namely (i) contamination of the GABA signal by signals from macromolecules and (ii) issues regarding the absolute quantification of MRS-measured GABA concentration. Secondly, this thesis describes an investigation of the role of GABA in the haemodynamic response as measured with functional magnetic resonance imaging. This multimodal study both brings together the methodological developments described earlier in the thesis into practical implementation and attempts to address certain unresolved issues with respect to associating GABA concentration with the haemodynamic response.

Item Type: Thesis (PhD)
Date Type: Publication
Status: Unpublished
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Uncontrolled Keywords: Magnetic resonance spectroscopy (MRS; Gamma-aminobutyric acid (GABA); Spectral editing; MEGA-PRESS; Magnetic resonance imaging (MRI);
Date of First Compliant Deposit: 18 May 2016
Date of Acceptance: 18 May 2016
Last Modified: 08 Nov 2016 06:25
URI: http://orca.cf.ac.uk/id/eprint/90981

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