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Murine Gammaherpesvirus-68 infection alters self-antigen presentation and Type 1 Diabetes onset in NOD Mice

Smith, Katherine A., Efstathiou, S. and Cooke, A. 2007. Murine Gammaherpesvirus-68 infection alters self-antigen presentation and Type 1 Diabetes onset in NOD Mice. The Journal of Immunology 179 (11) , pp. 7325-7333. 10.4049/jimmunol.179.11.7325

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Abstract

Recent research in line with the “hygiene hypothesis” has implicated virus infection in the delay or prevention of autoimmunity in murine models of type 1 diabetes such as the NOD mouse. We found that intraperitoneal or intranasal infection of NOD mice with the murine gammaherpesvirus-68 (MHV-68) significantly delayed diabetes onset in an age-dependent manner. The acute phase following intraperitoneal infection was associated with significantly reduced trafficking of autoreactive BDC2.5NOD CD4+ T cells to the pancreas but not the pancreatic lymph node (PLN); this was not as a result of MHV-68 M3 pan-chemokine binding protein expression. Autoreactive BDC2.5NOD CD4+ T cells within the PLN of MHV-68 infected mice were significantly more naive and proliferated to a lesser extent than those cells within the PLN of uninfected mice. These changes in autoreactive CD4+ T cell activation were associated with reduced dendritic cell endocytosis and soluble Ag presentation but were not as a result of virally induced IL-10 or changes in Ag-specific regulatory T cell populations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology > QR180 Immunology
Publisher: American Association of Immunologists
ISSN: 0022-1767
Date of Acceptance: 21 September 2007
Last Modified: 18 Jan 2017 05:35
URI: http://orca.cf.ac.uk/id/eprint/91202

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