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High b value q-space-analyzed diffusion MRI in vascular dementia: A preliminary study

Assaf, Yaniv, Mayzel-Oreg, O, Gigi, A, Ben-Bashat, D, Mordohovitch, M, Verchovsky, R, Reider-Groswasser, I.I, Hendler, T, Graif, M, Cohen, Y and Korczyn, A.D 2002. High b value q-space-analyzed diffusion MRI in vascular dementia: A preliminary study. Journal of the Neurological Sciences 203-20 , pp. 235-239. 10.1016/S0022-510X(02)00297-6

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High b value diffusion weighted magnetic resonance imaging (high-b DWI) was used to characterize white matter changes in the brain of patients with vascular dementia (VaD). Hyperintense white matter areas detected by T2-weighted magnetic resonance imaging (MRI) represent lesions, also termed leukoaraiosis that are very common in VaD as well as in other types of dementia. Therefore, the role of white matter changes in the cognitive and memory decline that occurs in VaD patients is still under debate. High-b DWI, analyzed using the q-space approach, is a more sensitive MRI method for detection of white matter changes. High-b DWI revealed massive white matter loss in VaD patients that surpassed the boundaries of T2 hyperintensities. This technique, therefore, might serve as a better indication for the extensive nerve fiber loss in the white matter that is caused by vascular disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Elsevier
ISSN: 0022-510X
Last Modified: 21 Aug 2019 02:19

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