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High b-value diffusion imaging of dementia: Application to vascular dementia and alzheimer disease

Mayzel-Oreg, Orna, Assaf, Yaniv, Gigi, Ariela, Ben-Bashat, Dafna, Verchovsky, Ruth, Mordohovitch, M., Graif, M., Hendler, Talma, Korczyn, Amos and Cohen, Yoram 2007. High b-value diffusion imaging of dementia: Application to vascular dementia and alzheimer disease. Journal of the Neurological Sciences 257 (1-2) , pp. 105-113. 10.1016/j.jns.2007.01.048

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Abstract

Alzheimer's disease (AD) and Vascular Dementia (VaD) are the most common types of dementia and are progressive diseases affecting millions of people. Despite the high sensitivity of MRI to neurological disorders it has not thus far been found to be specific for the detection of either of these pathologies. In the present study high b-value q-space diffusion-weighted MRI (DWI) was applied to VaD and AD. Controls (N=4), VaD patients (N=8) and AD patients (N=6) were scanned with high b-value DWI, which emphasizes the water component which exhibits restricted diffusion. VaD patients were found to present major WM loss while, in AD, the major pathology found was GM changes, as expected. Also, WM changes in VaD and AD were of a different pattern, more specific to frontal and temporal areas in AD and more widespread in VaD. This pattern of WM changes may be utilized as a diagnosis criterion. Conventional diffusion tensor imaging did not show significant changes between either of the groups and controls. These results demonstrate the potential of high b-value DWI in the diagnosis of dementia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Elsevier
ISSN: 0022-510X
Last Modified: 21 Aug 2019 02:19
URI: http://orca.cf.ac.uk/id/eprint/91843

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