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Synthesis, characterization and biological evaluation of some new oxino bis-pyrazole derivatives

Ghafoor, Abdul, Aslam, Noreen, Elliott, Mark Christopher, Sajid, Naveed, Nasrullah, Muhammad, Ashraf, Muhammad, Ain, Qurat-ul- and Khan, Misbahul Ain 2016. Synthesis, characterization and biological evaluation of some new oxino bis-pyrazole derivatives. Asian Journal of Chemistry 28 (8) , pp. 1648-1652. 10.14233/ajchem.2016.19736

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Abstract

Novel oxino bis-pyrazoles were obtained by two step reactions of 3-methyl-1-phenyl pyrazoline-5-one, cyanoacetamide and aryl- or alkylaldehydes, in the presence of catalytic amounts of triethylamine and ethanol as a solvent. All the synthesized compounds were evaluated for their inhibitory activities against butyrylcholinesterase (BChE) and bovine a-chymotrypsin. Two compounds, 8 and 9 were found to be good inhibitors of enzyme BChE with IC50 values of 52.74 ± 0.006 and 51.85 ± 0.005 μM, respectively.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Asian Journal of Chemistry
ISSN: 0970-7077
Date of First Compliant Deposit: 16 June 2016
Date of Acceptance: 24 March 2016
Last Modified: 04 Jun 2017 09:12
URI: http://orca.cf.ac.uk/id/eprint/91905

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