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Cytotoxic T lymphocytes, chemokines and antiviral immunity

Price, David, Klenerman, Paul, Booth, Bruce L, Phillips, Rodney E and Sewell, Andrew K 1999. Cytotoxic T lymphocytes, chemokines and antiviral immunity. Immunology Today 20 (5) , pp. 212-216. 10.1016/S0167-5699(99)01447-4

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Abstract

Evidence that CD8+ CTLs produce chemokines following engagement of viral antigens, and that MIP-1α is required for an inflammatory response to virus challenge, suggests that these molecules are key elements in the generation of effective antiviral immunity. Here, David Price and colleagues argue that the antigen-dependent release of chemokines by CTLs provides an elegant mechanism linking localization, amplification and coordination of the antiviral immune response to specific recognition of infected host cells beyond the confines of the lymphoid system.

Item Type: Article
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology > QR180 Immunology
Publisher: Elsevier
ISSN: 0167-5699
Date of First Compliant Deposit: 16 June 2016
Last Modified: 04 Jun 2017 09:12
URI: http://orca.cf.ac.uk/id/eprint/91915

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