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Visualization of cortical lamination patterns with magnetic resonance imaging

Barazany, D. and Assaf, Yaniv 2012. Visualization of cortical lamination patterns with magnetic resonance imaging. Cerebral Cortex 22 (9) , pp. 2016-2023. 10.1093/cercor/bhr277

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Abstract

The ability to image the cortex laminar arrangements in vivo is one of the holy grails of neuroscience. Recent studies have visualized the cortical layers ex vivo and in vivo (on a small region of interest) using high-resolution T1/T2 magnetic resonance imaging (MRI). In this study, we used inversion-recovery (IR) MRI to increase the sensitivity of MRI toward cortical architecture and achieving whole-brain characterization of the layers, in vivo, in 3D on humans and rats. Using the IR measurements, we computed 3D signal intensity plots along the cortex termed corticograms to characterize cortical substructures. We found that cluster analyses of the multi-IR images along the cortex divides it into at least 6 laminar compartments. To validate our observations, we compared the IR-MRI analysis with histology and revealed a correspondence, although these 2 measures do not represent similar quantities. The abilities of the method to segment the cortex into layers were demonstrated on the striate cortex (visualizing the stripe of Gennari) and on the frontal cortex. We conclude that the presented methodology can serve as means to study and characterize individual cortical architecture and organization.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Oxford University Press
ISSN: 1047-3211
Last Modified: 21 Aug 2019 02:21
URI: http://orca.cf.ac.uk/id/eprint/92239

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