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A randomized, controlled trial of a multi-modal exercise intervention in Huntington's disease

Quinn, Lori, Hamana, Katy, Kelson, Mark, Dawes, Helen, Collett, Johnny, Townson, Julia, Roos, Raymund, van der Plas, Anton Adriaan, Reilmann, Ralf, Frich, Jan C., Rickards, Hugh, Rosser, Anne and Busse, Monica 2016. A randomized, controlled trial of a multi-modal exercise intervention in Huntington's disease. Parkinsonism and Related Disorders 31 , pp. 46-52. 10.1016/j.parkreldis.2016.06.023

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Abstract

Introduction This study aimed to evaluate the feasibility and benefit of a structured exercise intervention in people with Huntington’s Disease (HD). Methods This study was conducted at 6 sites, and participants were randomized into either exercise or control (usual care) groups, and were assessed at baseline, 13 and 26 weeks. The intervention was a 12 week, three times per week progressive exercise program, including aerobic (stationary cycling) and upper and lower body strengthening exercise with tapered 1:1 support for 20 of 36 sessions. Results 314 adults were assessed for eligibility: 248 did not meet inclusion criteria, 34 declined, and 32 were recruited and randomized. Three individuals in the intervention group were withdrawn within the first month due to concomitant medical conditions, resulting in 14 participants in intervention and 15 in control groups. There were two AEs in the intervention group, both related to previous medical conditions, and there were two SAEs, both in the control group. The intervention group had better fitness (predicted VO2 max difference: 492.3 ml min−1, 95% CI: [97.1, 887.6]), lower UHDRS mMS (difference 2.9 points, 95% [−5.42, −0.32]) and lower weight at Week 13 (difference 2.25 kg, 95% CI: [−4.47, −0.03]). Conclusion This study demonstrates that a short-term exercise intervention is safe and feasible. Individuals with HD may benefit from structured exercise, and intensity, monitoring and support may be key factors in optimizing response. Larger scale trials are now required to fully elucidate the extended clinical potential of exercise in HD. Trial registration: Current Controlled Trials ISRCTN11392629.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 1353-8020
Funders: Jacques and Gloria Gossweiller Foundation
Date of First Compliant Deposit: 13 July 2016
Date of Acceptance: 30 June 2016
Last Modified: 05 Aug 2020 01:47
URI: http://orca.cf.ac.uk/id/eprint/92526

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