Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Structural plasticity underlies experience-dependent functional plasticity of cortical circuits

Wilbrecht, Linda, Holtmaat, Anthony, Wright, Nicholas Fraser, Fox, Kevin Dyson and Svoboda, Karel 2010. Structural plasticity underlies experience-dependent functional plasticity of cortical circuits. The Journal of Neuroscience 30 (14) , pp. 4927-4932. 10.1523/JNEUROSCI.6403-09.2010

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution Non-commercial Share Alike.

Download (1MB) | Preview

Abstract

The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote αCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that αCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Biosciences
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.jneurosci.org/site/misc/ifa_policies.xhtml#copyright (accessed 26/02/2014).
Publisher: Society for Neuroscience
ISSN: 0270-6474
Funders: MRC
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 02:07
URI: http://orca.cf.ac.uk/id/eprint/9283

Citation Data

Cited 78 times in Google Scholar. View in Google Scholar

Cited 97 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics