Matrix metalloproteinase 9 mRNA: An early prognostic marker for patients with acute stroke

Graham, Colin A., Chan, Rebecca W.Y., Chan, Dexter Y.S., Chan, Cangel P.Y., Wong, Lawrence K.S. and Rainer, Timothy ORCID: https://orcid.org/0000-0003-3355-3237 2011. Matrix metalloproteinase 9 mRNA: An early prognostic marker for patients with acute stroke. Clinical Biochemistry 45 (4-5) , pp. 352-355. 10.1016/j.clinbiochem.2011.12.006

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Abstract

To investigate matrix metalloproteinase 9 (MMP9) mRNA as a prognostic marker in stroke. Design and methods MMP9 mRNA concentrations in 126 stroke patients were analyzed using quantitative reverse transcription-polymerase chain reaction. Results The normalized MMP9 mRNA concentration was almost 3 times higher in non-survival patients compared to survival patients (P = 0.0002); and 1.9-fold higher in patients with post-stroke modified Rankin score (mRS) > 2 than patients with mRS ≤ 2 (P < 0.05). Conclusions MMP9 mRNA was a predictor of poor outcome and mortality in stroke.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Blood–brain barrier; Messenger RNA (mRNA); Matrix metalloproteinase 9 (MMP9); Prognostic; Stroke
Publisher:	Elsevier
ISSN:	0009-9120
Date of Acceptance:	6 December 2011
Last Modified:	01 Nov 2022 10:50
URI:	https://orca.cardiff.ac.uk/id/eprint/93028

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