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Preventing fractures among older people living in institutional care: a pragmatic randomised double blind placebo controlled trial of vitamin D supplementation

Lyons, R. A., Johansen, A., Brophy, S., Newcombe, Robert G., Phillips, C. J., Lervy, B., Evans, R., Wareham, K. and Stone, Michael D. 2007. Preventing fractures among older people living in institutional care: a pragmatic randomised double blind placebo controlled trial of vitamin D supplementation. Osteoporosis International 18 (6) , pp. 811-818. 10.1007/s00198-006-0309-5

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Abstract

Introduction Osteoporotic fractures in older people are a major and increasing public health problem. We examined the effect of vitamin D supplementation on fracture rate in people living in sheltered accommodation. Methods In a pragmatic double blind randomised controlled trial of 3 years duration, we examined 3,440 people (2,624 women and 816 men) living in residential or care home. We used four-monthly oral supplementation using 100,000 IU vitamin D2 (ergocalciferol). As a main outcome measure, we used the incidence of first fracture using an intention to treat analysis. This was a multicentre study in 314 care homes or sheltered accommodation complexes in South Wales, UK. Results The vitamin D and placebo groups had similar baseline characteristics. In intention-to-treat analysis, 205 first fractures occurred in the intervention group during a total of 2,846 person years of follow-up (7 fractures per 100 people per year of follow-up), with 218 first fractures in the control group over 2,860 person years of follow-up. The hazard ratio of 0.95 (95% confidence interval 0.79–1.15) for intervention compared to control was not statistically significant. Conclusion Supplementation with four-monthly 100,000 IU of oral vitamin D2 is not sufficient to affect fracture incidence among older people living in institutional care.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Fracture, Institutional care, Prevention, Randomised controlled trial, Vitamin D
ISSN: 0937-941X
Date of Acceptance: 1 December 2006
Last Modified: 28 Dec 2017 20:38
URI: http://orca.cf.ac.uk/id/eprint/93294

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