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Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing

Feng, Yi, Sanders, Andrew, Ruge, Fiona, Morris, Ceri, Harding, Keith and Jiang, Wen 2016. Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing. International Journal of Molecular Medicine 38 (5) , pp. 1349-1358. 10.3892/ijmm.2016.2733

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Abstract

Cytokines play important roles in the wound healing process through various signalling pathways. The JAK-STAT pathway is utilised by most cytokines for signal transduction and is regulated by a variety of molecules, including suppressor of cytokine signalling (SOCS) proteins. SOCS are associated with inflammatory diseases and have an impact on cytokines, growth factors and key cell types involved in the wound‑healing process. SOCS, a negative regulator of cytokine signalling, may hold the potential to regulate cytokine‑induced signalling in the chronic wound‑healing process. Wound edge tissues were collected from chronic venous leg ulcer patients and classified as non-healing and healing wounds. The expression pattern of seven SOCSs members, at the transcript and protein level, were examined in these tissues using qPCR and immunohistochemistry. Significantly higher levels of SOCS3 (P=0.0284) and SOCS4 (P=0.0376) in non-healing chronic wounds compared to the healing/healed chronic wounds were observed at the transcript level. Relocalisation of SOCS3 protein in the non-healing wound environment was evident in the investigated chronic biopsies. Thus, the results show that the expression of SOCS transcript indicated that SOCS members may act as a prognostic biomarker of chronic wounds

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: suppressor of cytokine signalling; chronic wound; biopsies
Publisher: Spandidos Publications
ISSN: 1107-3756
Funders: GSK Foundation, Cancer Research Wales
Related URLs:
Date of First Compliant Deposit: 24 August 2016
Date of Acceptance: 2 August 2016
Last Modified: 12 Aug 2019 16:19
URI: http://orca.cf.ac.uk/id/eprint/94038

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