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Self-assembled palladium and platinum coordination cages: Photophysical studies and anticancer activity

Kaiser, Felix, Schmidt, Andrea, Heydenreuter, Wolfgang, Altmann, Philipp Johannes, Casini, Angela, Sieber, Stephan A. and Kühn, Fritz Elmar 2016. Self-assembled palladium and platinum coordination cages: Photophysical studies and anticancer activity. European Journal of Inorganic Chemistry 2016 (33) , pp. 5189-5196. 10.1002/ejic.201600811

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Abstract

Self-assembled coordination cages are interesting as drug delivery systems. Therefore, the synthesis of new ML (M = Pd, Pt) molecular cages, derived from highly fluorescent, rigid polyaromatic ligands is reported and the first PtL cage with a ligand consisting of three pyridine moieties is described. Photophysical properties were examined showing high quantum yieldsof up to 48% for the methoxy-functionalized ligands. Coordination of the ligands to palladium and platinum ions reduces the metallocages' fluorescence, however. The host-guest chemistry of the palladium cage with cisplatin is investigated confirming the encapsulation. The cages encapsulating cisplatin show a significantly increased cytotoxicity towards A549 (human lung adenocarcinoma) cells compared to cisplatin, and thus appear to be promising delivery vectors for the anticancer drug cisplatin.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Wiley
ISSN: 1434-1948
Date of First Compliant Deposit: 5 September 2016
Date of Acceptance: 23 August 2016
Last Modified: 18 Oct 2019 14:52
URI: http://orca.cf.ac.uk/id/eprint/94190

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