Bicatalytic multistep reactions en route to the one-pot total synthesis of complex molecules: easy access to chromene and 1,2-dihydroquinoline derivatives from simple substrates

Giorgi, Pascal D., Miedziak, Peter J., Edwards, Jennifer K., Hutchings, Graham J. and Antoniotti, Sylvain 2017. Bicatalytic multistep reactions en route to the one-pot total synthesis of complex molecules: easy access to chromene and 1,2-dihydroquinoline derivatives from simple substrates. ChemCatChem 9 (1) , pp. 70-75. 10.1002/cctc.201600925

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Abstract

By combining nanocatalysis and base-catalysis, a novel one-pot multistep process was found for the synthesis of substituted heterocycles of biological relevance from simple substrates. It is based on an initial Au/O2 oxidation of allylic alcohols followed by a base-catalysed tandem hetero-Michael/aldolisation/crotonisation with ortho-hydroxy or ortho-amino benzaldehydes. The flexibility of the reaction even allowed the benzaldehyde partner to be prepared in situ in an example of one-pot/5-steps process.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Subjects:	Q Science > QD Chemistry
Publisher:	Wiley
ISSN:	1867-3880
Funders:	EPSRC
Date of First Compliant Deposit:	8 September 2016
Date of Acceptance:	7 September 2016
Last Modified:	20 Jan 2021 15:35
URI:	http://orca.cf.ac.uk/id/eprint/94373

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