Giorgi, Pascal D., Miedziak, Peter J., Edwards, Jennifer K., Hutchings, Graham J. and Antoniotti, Sylvain
2017.
Bicatalytic multistep reactions en route to the one-pot total synthesis of complex molecules: easy access to chromene and 1,2-dihydroquinoline derivatives from simple substrates.
ChemCatChem
9
(1)
, pp. 70-75.
10.1002/cctc.201600925
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Abstract
By combining nanocatalysis and base-catalysis, a novel one-pot multistep process was found for the synthesis of substituted heterocycles of biological relevance from simple substrates. It is based on an initial Au/O2 oxidation of allylic alcohols followed by a base-catalysed tandem hetero-Michael/aldolisation/crotonisation with ortho-hydroxy or ortho-amino benzaldehydes. The flexibility of the reaction even allowed the benzaldehyde partner to be prepared in situ in an example of one-pot/5-steps process.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry Cardiff Catalysis Institute (CCI) |
Subjects: | Q Science > QD Chemistry |
Publisher: | Wiley |
ISSN: | 1867-3880 |
Funders: | EPSRC |
Date of First Compliant Deposit: | 8 September 2016 |
Date of Acceptance: | 7 September 2016 |
Last Modified: | 20 Jan 2021 15:35 |
URI: | http://orca.cf.ac.uk/id/eprint/94373 |
Citation Data
Cited 3 times in Google Scholar. View in Google Scholar
Cited 6 times in Scopus. View in Scopus. Powered By Scopus® Data
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