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Methods of epigenome editing for probing the function of genomic imprinting

Rienecker, Kira, Hill, Matthew and Isles, Anthony Roger 2016. Methods of epigenome editing for probing the function of genomic imprinting. Epigenomics 8 (10) , pp. 1389-1398. 10.2217/epi-2016-0073

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Abstract

The curious patterns of imprinted gene expression draw interest from several scientific disciplines to the functional consequences of genomic imprinting. Methods of probing the function of imprinting itself have largely been indirect and correlational, relying heavily on conventional transgenics. Recently, the burgeoning field of epigenome editing has provided new tools and suggested strategies for asking causal questions with site specificity. This perspective article aims to outline how these new methods may be applied to questions of functional imprinting and, with this aim in mind, to suggest new dimensions for the expansion of these epigenome-editing tools.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Future Medicine
ISSN: 1750-1911
Date of First Compliant Deposit: 24 October 2016
Date of Acceptance: 5 August 2016
Last Modified: 29 Jun 2019 16:22
URI: http://orca.cf.ac.uk/id/eprint/95316

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