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Neural correlates of the LSD experience revealed by multimodal neuroimaging

Carhart-Harris, Robin L., Muthukumaraswamy, Suresh, Roseman, Leor, Kaelen, Mendel, Droog, Wouter, Murphy, Kevin, Tagliazucchi, Enzo, Schenberg, Eduardo E., Nest, Timothy, Orban, Csaba, Leech, Robert, Williams, Luke T., Williams, Tim M., Bolstridge, Mark, Sessa, Ben, McGonigle, John, Sereno, Martin I., Nichols, David, Hellyer, Peter J., Hobden, Peter, Evans, Christopher John, Singh, Krish Devi, Wise, Richard Geoffrey, Curran, H. Valerie, Feilding, Amanda and Nutt, David J. 2016. Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences of the United States of America 113 (17) , pp. 4853-4858. 10.1073/pnas.1518377113

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Abstract

Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimaging techniques: arterial spin labeling (ASL), blood oxygen level-dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD that correlated strongly with its characteristic psychological effects. Increased visual cortex cerebral blood flow (CBF), decreased visual cortex alpha power, and a greatly expanded primary visual cortex (V1) functional connectivity profile correlated strongly with ratings of visual hallucinations, implying that intrinsic brain activity exerts greater influence on visual processing in the psychedelic state, thereby defining its hallucinatory quality. LSD’s marked effects on the visual cortex did not significantly correlate with the drug’s other characteristic effects on consciousness, however. Rather, decreased connectivity between the parahippocampus and retrosplenial cortex (RSC) correlated strongly with ratings of “ego-dissolution” and “altered meaning,” implying the importance of this particular circuit for the maintenance of “self” or “ego” and its processing of “meaning.” Strong relationships were also found between the different imaging metrics, enabling firmer inferences to be made about their functional significance. This uniquely comprehensive examination of the LSD state represents an important advance in scientific research with psychedelic drugs at a time of growing interest in their scientific and therapeutic value. The present results contribute important new insights into the characteristic hallucinatory and consciousness-altering properties of psychedelics that inform on how they can model certain pathological states and potentially treat others.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Physics and Astronomy
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: National Academy of Sciences
ISSN: 0027-8424
Date of Acceptance: 1 March 2016
Last Modified: 25 May 2019 22:17
URI: http://orca.cf.ac.uk/id/eprint/95413

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