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Vitamin D for the management of asthma (Review)

Martineau, Adrian R., Cates, Christopher J., Urashima, Mitsuyoshi, Jensen, Megan, Griffiths, Alex P., Nurmatov, Ulugbek, Sheikh, Aziz and Griffiths, Chris J. 2016. Vitamin D for the management of asthma (Review). Cochrane Database of Systematic Reviews (9) , CD011511. 10.1002/14651858.CD011511.pub2

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Background Several clinical trials of vitamin D to prevent asthma exacerbation and improve asthma control have been conducted in children and adults, but a meta-analysis restricted to double-blind, randomised, placebo-controlled trials of this intervention is lacking. Objectives To evaluate the efficacy of administration of vitamin D and its hydroxylated metabolites in reducing the risk of severe asthma exacerbations (defined as those requiring treatment with systemic corticosteroids) and improving asthma symptom control. Search methods We searched the Cochrane Airways Group Trial Register and reference lists of articles.We contacted the authors of studies in order to identify additional trials. Date of last search: January 2016. Selection criteria Double-blind, randomised, placebo-controlled trials of vitamin D in children and adults with asthma evaluating exacerbation risk or asthma symptom control or both. Data collection and analysis Two review authors independently applied study inclusion criteria, extracted the data, and assessed risk of bias. We obtained missing data from the authors where possible. We reported results with 95% confidence intervals (CIs).

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Cochrane Collaboration. Published by JohnWiley & Sons, Ltd.
ISSN: 1469-493X
Date of First Compliant Deposit: 20 October 2016
Date of Acceptance: 5 September 2016
Last Modified: 04 Jun 2017 09:28

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