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Structural classification of insecticidal proteins - Towards an in silico characterisation of novel toxins

Berry, Colin and Crickmore, Neil 2016. Structural classification of insecticidal proteins - Towards an in silico characterisation of novel toxins. Journal of Invertebrate Pathology 142 , pp. 16-22. 10.1016/j.jip.2016.07.015

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Abstract

The increasing rate of discovery of new toxins with potential for the control of invertebrate pests through next generation sequencing, presents challenges for the identification of the best candidates for further development. A consideration of structural similarities between the different toxins suggest that they may be functionally less diverse than their low sequence similarities might predict. This is encouraging from the prospective of being able to use computational tools to predict toxin targets from their sequences, however more structure/function data are still required to reliably inform such predictions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: Bacillus thuringiensis; Lysinibacillus sphaericus; Cry toxin
Publisher: Elsevier
ISSN: 0022-2011
Date of First Compliant Deposit: 8 November 2016
Date of Acceptance: 28 July 2016
Last Modified: 02 Aug 2017 09:47
URI: http://orca.cf.ac.uk/id/eprint/95739

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