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Frontispiece: stereoselective ketone rearrangements with hypervalent iodine reagents

Malmedy, Florence and Wirth, Thomas 2016. Frontispiece: stereoselective ketone rearrangements with hypervalent iodine reagents. Chemistry - a European Journal 22 (45) , pp. 16072-16077. 10.1002/chem.201684562

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Abstract

Stereoselective Rearrangements The first stereoselective version of an iodine(III)-mediated rearrangement of arylketones in the presence of orthoesters is described T. Wirth and F. Malmedy on page 16072 ff. The reaction products, α-arylated esters, are very useful intermediates in the synthesis of bioactive compounds, such as ibuprofen. With chiral lactic acid-based iodine(III) reagents, enantioselectivities of up to 73 % ee have been achieved.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: WileyBlackwell
ISSN: 0947-6539
Date of First Compliant Deposit: 10 November 2016
Date of Acceptance: 21 October 2016
Last Modified: 21 Oct 2017 15:41
URI: http://orca.cf.ac.uk/id/eprint/96000

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