Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Harmonising data collection from osteoarthritis studies to enable stratification: recommendations on core data collection from an Arthritis Research UK clinical studies group

Kingsbury, Sarah R., Corp, Nadia, Watt, Fiona E., Felson, David T., O'Neill, Terence W., Holt, Catherine Avril, Jones, Richard K., Conaghan, Philip G. and Arden, Nigel K. 2016. Harmonising data collection from osteoarthritis studies to enable stratification: recommendations on core data collection from an Arthritis Research UK clinical studies group. Rhuematology 55 (8) , pp. 1394-1402. 10.1093/rheumatology/kew201

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (160kB) | Preview

Abstract

Objective. Treatment of OA by stratifying for commonly used and novel therapies will likely improve the range of effective therapy options and their rational deployment in this undertreated, chronic disease. In order to develop appropriate datasets for conducting post hoc analyses to inform approaches to stratification for OA, our aim was to develop recommendations on the minimum data that should be recorded at baseline in all future OA interventional and observational studies. Methods. An Arthritis Research UK study group comprised of 32 experts used a Delphi-style approach supported by a literature review of systematic reviews to come to a consensus on core data collection for OA studies. Results. Thirty-five systematic reviews were used as the basis for the consensus group discussion. For studies with a primary structural endpoint, core domains for collection were defined as BMI, age, gender, racial origin, comorbidities, baseline OA pain, pain in other joints and occupation. In addition to the items generalizable to all anatomical sites, joint-specific domains included radiographic measures, surgical history and anatomical factors, including alignment. To demonstrate clinical relevance for symptom studies, the collection of mental health score, self-efficacy and depression scales were advised in addition to the above. Conclusions. Currently it is not possible to stratify patients with OA into therapeutic groups. A list of core and optional data to be collected in all OA interventional and observational studies was developed, providing a basis for future analyses to identify predictors of progression or response to treatment.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Engineering
Subjects: R Medicine > R Medicine (General)
Publisher: Oxford University Press
ISSN: 1462-0324
Funders: Arthritis Research UK
Date of First Compliant Deposit: 11 November 2016
Date of Acceptance: 31 March 2016
Last Modified: 04 Jun 2017 09:30
URI: http://orca.cf.ac.uk/id/eprint/96060

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics