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Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

Hill, Stephen A., Benito-Alifonso, David., Morgan, David John, Davis, Sean A., Berry, Monica and Galan, M. Carmen 2016. Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery. Nanoscale 8 (44) , pp. 18630-18634. 10.1039/C6NR07336K

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Abstract

A one-pot, three-minute, gram-scale synthesis of novel sp3-nanocrystalline, water-soluble, and fluorescent carbon dots (FCDs), from simple and cheap sugar starting materials is described. Mechanism studies showed that NH2-FCD formation proceeds via a crucial imine intermediate derived from reaction between a sugar hemiacetal and an amine. Moreover, we successfully demonstrate the utility of lactose functionalized FCDots (Lac-FCDots) as non-toxic fluorescent intracellular delivery vehicles.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Cardiff Catalysis Institute (CCI)
Chemistry
Subjects: Q Science > QD Chemistry
Publisher: RSC Publishing
ISSN: 2040-3364
Funders: EPSRC
Date of First Compliant Deposit: 1 December 2016
Date of Acceptance: 20 October 2016
Last Modified: 04 Jun 2017 09:32
URI: http://orca.cf.ac.uk/id/eprint/96551

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