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The ProTides boom

Mehellou, Youcef 2016. The ProTides boom. Chemmedchem 11 (11) , pp. 1114-1116. 10.1002/cmdc.201600156

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The masking of nucleoside phosphate and phosphonate groups by an aryl motif and an amino acid ester, nowadays known as the ‘ProTide’ technology, has proven to be effective in the discovery of nucleotide therapeutics. Indeed, this technology, which was invented by Chris McGuigan in the early 1990s, has inspired the discovery of two FDA-approved antiviral nucleotide drugs, and many more are currently undergoing (pre)clinical development. The usefulness of this technology in the discovery of nucleotide therapeutics is showcased in this Highlight by discussing the ProTides development and the various ProTides that have reached clinical trials.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Publisher: Wiley
ISSN: 1860-7179
Date of First Compliant Deposit: 13 March 2017
Date of Acceptance: 7 April 2016
Last Modified: 04 Jun 2017 09:35

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