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Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke

Ahmed, Jewel, Dwyer, Dominic, Farr, Tracy D, Harrison, David, Dunnett, Stephen and Trueman, Rebecca C 2017. Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke. Journal of Cerebral Blood Flow & Metabolism 37 (3) , pp. 755-761. 10.1177/0271678X16684141

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Abstract

The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral artery occlusion in rats. Impairments in drinking efficiency compared to controls, and a compensatory increase in the number of drinking clusters were observed. This highlights the utility of this easy to administer task in assessing subtle, long-term deficits, which could be likened to oral deficits in patients.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Sage
ISSN: 0271678X
Funders: MRC
Date of First Compliant Deposit: 11 January 2017
Date of Acceptance: 21 October 2016
Last Modified: 24 Feb 2019 23:15
URI: http://orca.cf.ac.uk/id/eprint/97346

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