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Soluble toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission

Holst, Benjamin, Szakmany, Tamas, Raby, Anne-Catherine, Hamlyn, Vincent, Durno, Kimberley, Hall, Judith Elizabeth and Labéta, Mario O. 2017. Soluble toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission. Intensive Care Medicine Experimental 5 (1) 10.1186/s40635-016-0116-z

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Abstract

Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been evaluated. 37 patients with a diagnosis of severe sepsis/septic shock (sepsis) and 27 patients with organ failure without infection (SIRS) were studied. Median (IQR) plasma sTLR2 levels were 2.7 ng/ml (1.4–6.1) in sepsis and 0.6 ng/ml (0.4–0.9) in SIRS p < 0.001. sTLR2 showed good diagnostic value for sepsis at cut-off of 1.0 ng/ml, AUC:0.959. We report the ability of sTLR2 levels to discriminate between sepsis and SIRS within 12 h of ICU admission in patients with multi-organ failure.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Springer
ISSN: 2197-425X
Funders: Wellcome Trust
Date of First Compliant Deposit: 13 January 2017
Date of Acceptance: 29 December 2016
Last Modified: 06 Sep 2017 08:12
URI: http://orca.cf.ac.uk/id/eprint/97414

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