Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopath

Dhillon, Rana S., Parker, John, Syed, Yasir A., Edgley, Steve, Young, Adam, Fawcett, James W., Jeffery, Nick D., Franklin, Robin J. M. and Kotter, Mark R. N. 2016. Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopath. Acta Neuropathologica Communications 4 (1) , 89. 10.1186/s40478-016-0359-7

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (2MB) | Preview

Abstract

Cervical spondylotic myelopathy (CSM) is the most common spinal cord disorder and a major cause of disability in adults. Improvements following surgical decompression are limited and patients often remain severely disabled. Post mortem studies indicate that CSM is associated with profound axonal loss. However, our understanding of the pathophysiology of CSM remains limited. To investigate the hypothesis that axonal plasticity plays a role in the recovery following surgical decompression, we adopted a novel preclinical model of mild to moderate CSM. Spinal cord compression resulted in significant locomotor deterioration, increased expression of the axonal injury marker APP, and loss of serotonergic fibres. Surgical decompression partially reversed the deficits and attenuated APP expression. Decompression was also associated with axonal sprouting, reflected in the restoration of serotonergic fibres and an increase of GAP43 expression. The re-expression of synaptophysin indicated the restoration of functional synapses following decompression. Promoting axonal plasticity may therefore be a therapeutic strategy for promoting neurological recovery in CSM.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: BioMed Central
ISSN: 2051-5960
Date of First Compliant Deposit: 16 February 2017
Date of Acceptance: 1 August 2016
Last Modified: 04 Jun 2017 09:41
URI: http://orca.cf.ac.uk/id/eprint/98201

Citation Data

Cited 11 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics