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BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation

Palego, C., Perry, G., Hancock, C., Hjeij, F., Dalmay, C., Bessaudou, A., Blondy, P., Pothier, A., Lalloue, F., Bessette, B., Begaud, G., Jauberteau, M-O., Kaynak, C.B., Wietstruck, M., Kaynak, M., Casbon, M., Benedikt, J., Barrow, D. and Porch, Adrian 2016. BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation. Presented at: 2016 IEEE MTT-S International Microwave Symposium (IMS), San Francisco, CA, USA, 22-27 May 2016. 2016 IEEE MTT-S International Microwave Symposium (IMS). IEEE, pp. 1-4. 10.1109/MWSYM.2016.7540266

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Abstract

A novel microfluidic biosensing platform based on Bipolar-Complementary Oxide Semiconductor (BiCMOS) technology is presented. The device relies on a quadruple electrode system and a microfluidic channel that are directly integrated into the back-end-of-line (BEOL) of the BiCMOS stack. For proof of concept repeatable electrical trapping of single SW620 (colon cancer) cells in the quadruple electrode system is initially demonstrated. Additionally, for the first time a microwave intermodulation technique is used for high sensitivity dielectric spectroscopy, which could pave the way to label-free monitoring of intracellular processes and manipulation such as electroporation.

Item Type: Conference or Workshop Item (Paper)
Date Type: Publication
Status: Published
Schools: Engineering
Subjects: T Technology > TK Electrical engineering. Electronics Nuclear engineering
Publisher: IEEE
ISBN: 978-1-5090-0698-4
Last Modified: 04 Jul 2019 10:53
URI: http://orca.cf.ac.uk/id/eprint/98310

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