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Naeem Khan, Robert K. Hills, Steve Knapper, Lora Steadman, Ushna Qureshi, Jerrald L. Rector, Charlotte Bradbury, Nigel H. Russell, Paresh Vyas, Alan K. Burnett, David Grimwade, Paul S. Hole, Sylvie D. Freeman
Normal Hematopoietic Progenitor Subsets Have Distinct Reactive Oxygen Species, BCL2 and Cell-Cycle Profiles That Are Decoupled from Maturation in Acute Myeloid Leukemia
www.plosone.org
www.plosone.org
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[(=,1)]TJ
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[()]TJ
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BT
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[(#')]TJ
1.525 0 Td
[()6()11()-6()-4()]TJ
2.0126 0 Td
[(,:&')]TJ
ET
Q
q
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1 J
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7.4999 0 0 6.6659 558.9354 524.9763 cm
BT
/F7 1 Tf
1 TL
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[(>.)]TJ
ET
Q
q
1 j
1 J
0 w
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BT
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[(,:&3)]TJ
ET
Q
q
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1 J
0 w
7.4999 0 0 6.6659 223.4834 511.9937 cm
BT
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[()2()1()-6()]TJ
ET
Q
q
1 j
1 J
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10 0 0 10 239.0173 507.5149 cm
BT
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[()-1()5()-5()3(\n)]TJ
1.9218 0 Td
[()-11( )2()-6()-5()2()11()]TJ
3.6794 0 Td
[()-1()11()19()-6()8()1()2()1()8()]TJ
4.4844 0 Td
[()-1()11()2()2()12()10()6()-6()]TJ
4.5694 0 Td
[()11( )13()1()7()1()2()12()6()11( )7(\n)]TJ
5.1647 0 Td
[()3()2()]TJ
1.7064 0 Td
[()2()1()-6()4()1( )]TJ
2.7893 0 Td
[(:)-19(,5)]TJ
2.126 0 Td
[(\n)5()-6()8()1()2()1()8()]TJ
3.3902 0 Td
[()-4()3()8()]TJ
2.0352 0 Td
[()6()11()-6()-4()]TJ
-35.7672 -1.2982 Td
[(,:&')]TJ
ET
Q
q
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7.4999 0 0 6.6659 223.4834 499.011 cm
BT
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[(>)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 227.7354 494.5322 cm
BT
/F7 1 Tf
1 TL
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[(,:&3)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 251.2062 499.011 cm
BT
/F7 1 Tf
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[()2()15(\r)]TJ
ET
Q
q
1 j
1 J
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10 0 0 10 264.1322 494.5322 cm
BT
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[()-1()5()-5()3(\n)]TJ
1.9218 0 Td
[()-11( )2()-6()-5()2()11()]TJ
3.6794 0 Td
[()-1()11()19()-6()8()1()2()1()8()]TJ
4.4844 0 Td
[()4()11( )13()]TJ
2.313 0 Td
[()1()2()3()18()10()1( )13()]TJ
4.1556 0 Td
[()11(A,)]TJ
2.2507 0 Td
[()1(\n)]TJ
1.0261 0 Td
[()2()-9()-6()-6()6()-6()6(%)]TJ
3.9175 0 Td
[(5)20()1( )-10()-4()4()1( )]TJ
3.2428 0 Td
[()8()3()-4()7()1(\n)2()3(\n)]TJ
-33.4032 -1.2982 Td
[(\r)-3()12()-4()2()1()]TJ
2.795 0 Td
[()-4()4()2(\n)-7()]TJ
2.2507 0 Td
[()-2(\r)8()]TJ
1.7006 0 Td
[()1()2()19()1()4()11()6()4()1()4()11()-2()-1()11()2()]TJ
8.1468 0 Td
[()-1()11()19()-5()8( )-10()-5()4()1()19(\n)]TJ
6.015 0 Td
[( )13()1()11( )13()2(\n)-7()1()19()-6()18()-5()7()8()]TJ
6.1512 0 Td
[()2()8()19()6()2()2(\n)]TJ
3.9118 0 Td
[()1()]TJ
0.83 0.64 0.02 0 k
1.0261 0 Td
[(5)17()1()]TJ
1.457 0 Td
[()]TJ
0 g
[()]TJ
1.7348 0 Td
[()-1()11(.)]TJ
-35.189 -1.2983 Td
[()-11()1( )-4()4()-6()]TJ
2.8857 0 Td
[()-4()3()18()]TJ
1.7971 0 Td
[(+,)]TJ
2.1089 0 Td
[()3()2()]TJ
1.7064 0 Td
[()2()15(\r)]TJ
1.6498 0 Td
[(:)-19(,5)]TJ
2.1316 0 Td
[(\n)5()-6()8()1()2()1()8()]TJ
3.3846 0 Td
[()4()-6()1()-2()8()]TJ
3.5603 0 Td
[(\n)5()-6()8()4()-2()8( )13()1()3(\n)-7()-6(.:)-19(,5)20(.58)]TJ
9.632 0 Td
[(E)]TJ
0.7937 0 Td
[(#%7;")]TJ
2.4435 0 Td
[()1(\n)]TJ
1.0204 0 Td
[()1()2()]TJ
1.5251 0 Td
[()-4()4()]TJ
-34.6391 -1.3039 Td
[(A)5(A)]TJ
2.2337 0 Td
[()-9()11()11()-5()-2()18()-5()2()11()]TJ
4.575 0 Td
[()4()-6()1()-2()8()]TJ
3.5546 0 Td
[(%63%)]TJ
2.4435 0 Td
[(/)1()4()]TJ
1.7858 0 Td
[()1()2()-11( )13()-6(-)10()2()1()19()]TJ
4.388 0 Td
[( A)5(A)]TJ
2.7666 0 Td
[(\n)5()5()1(\n)-7()1()]TJ
2.6872 0 Td
[()]TJ
/F13 1 Tf
(<)Tj
/F7 1 Tf
[(;I)]TJ
2.5682 0 Td
[()11()]TJ
1.0091 0 Td
[(,:&')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 503.6031 460.0062 cm
BT
/F7 1 Tf
1 TL
0 0 Td
[(>)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 507.9118 455.5275 cm
BT
/F7 1 Tf
1 TL
0 0 Td
[(,:&3)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 531.3826 460.0062 cm
BT
/F7 1 Tf
1 TL
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[()2()15(\r)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 542.0976 455.5275 cm
BT
/F7 1 Tf
1 TL
0 0 Td
[()]TJ
0.5612 0 Td
[()3()2()]TJ
-34.7694 -1.2982 Td
[( )13()5()-2()18()-5()7()8()5()7()]TJ
3.838 0 Td
[()2()1()-6()4()1( )]TJ
2.7837 0 Td
[(:)-19(,5)]TJ
2.1259 0 Td
[(\n)5()-6()8()1()2()1()8()]TJ
3.3902 0 Td
[()4()-6()1()-2()8()]TJ
3.5603 0 Td
[(#%'3")]TJ
2.4378 0 Td
[()-1()11()19()-5()8( )13()-6()]TJ
4.2123 0 Td
[()6()]TJ
1.0261 0 Td
[()-9()11()-4()]TJ
2.0523 0 Td
[(+,)]TJ
2.1089 0 Td
[()8()4()]TJ
1.7235 0 Td
[(A)5(A)139(%)]TJ
2.4491 0 Td
[(8)17()19()6()1( )13()2(\n)5()-5()1()8()-6()7()]TJ
-31.7081 -1.2983 Td
[()-4()4()1( )13()]TJ
2.2507 0 Td
[(\r)1()1(\n)]TJ
1.7007 0 Td
[()]TJ
0.6577 0 Td
[()1()1()-11()8()1( )13()1()19()-5()-2()-4()]TJ
4.5807 0 Td
[()7()]TJ
2.041 0 Td
[()11( )13()11()-11()-5()2()]TJ
2.8289 0 Td
[(\r)-3()12()-4()2()1()]TJ
2.795 0 Td
[()-4()4()]TJ
1.474 0 Td
[(,:&')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 406.7149 433.9842 cm
BT
/F7 1 Tf
1 TL
0 0 Td
[(>)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 411.0236 429.5622 cm
BT
/F7 1 Tf
1 TL
0 0 Td
[(,:&3)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 434.4944 433.9842 cm
BT
/F7 1 Tf
1 TL
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[()2()1()-6()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 450.085 429.5622 cm
BT
/F7 1 Tf
1 TL
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[()-11( )2()-6()-5()2()11(K)]TJ
3.5546 0 Td
[(4A)]TJ
2.3811 0 Td
[()3()2()]TJ
1.7064 0 Td
[()2()1()-6()4()2(\n)5()]TJ
-32.6491 -1.3039 Td
[(:)-19(,5)]TJ
2.1259 0 Td
[(\n)5()-6()8()1()2()1()8()]TJ
3.3902 0 Td
[()4()-6()1()-2()8()]TJ
3.5547 0 Td
[(<%<'")]TJ
2.4434 0 Td
[()8()6()-5()2()15(\r)8()-6()]TJ
3.6283 0 Td
[()15()]TJ
1.1793 0 Td
[(,A)]TJ
2.3243 0 Td
[()4()-6()1()-2()8()]TJ
3.5603 0 Td
[(&%')]TJ
2.2224 0 Td
[()8()4()]TJ
1.7177 0 Td
[()-4()4()1()]TJ
2.0126 0 Td
[(DA)]TJ
2.2336 0 Td
[()4()-6()1()-2()8()]TJ
3.5603 0 Td
[(#%33)]TJ
-33.953 -1.2982 Td
[()-1()11()19()6()2()1()6()]TJ
4.2009 0 Td
[(\n)5()1()2()3()8( )-4()3(\n)-7()-6()]TJ
5.1023 0 Td
[()-2()18()-6()]TJ
1.9162 0 Td
[()1()]TJ
0.83 0.64 0.02 0 k
1.0262 0 Td
[(5)17()1()]TJ
1.457 0 Td
[(#)]TJ
1.3889 0 Td
[()8()4()]TJ
1.7235 0 Td
[(#1)]TJ
0 g
[(%)]TJ
1.8425 0 Td
[(/)1()4()]TJ
1.7858 0 Td
[()2()2()1( )8( )13()6()23()]TJ
4.0082 0 Td
[()1()]TJ
1.0203 0 Td
[(:)-19(,5)]TJ
2.126 0 Td
[(\n)5()-6()8()1()2()1()8()]TJ
3.3902 0 Td
[(\r)-3()12()-4()]TJ
-30.988 -1.2983 Td
[(4A)]TJ
/F13 1 Tf
(>)Tj
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[(,A)]TJ
/F13 1 Tf
(>)Tj
/F7 1 Tf
[(DA)]TJ
8.039 0 Td
[()8()4()]TJ
1.7234 0 Td
[( A)5(A)]TJ
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(>)Tj
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[(+,2A)5(A)]TJ
7.7556 0 Td
[(\r)1()1(\n)]TJ
1.7007 0 Td
[()-4()3(\n)-7()]TJ
1.7745 0 Td
[()5()1(\n)-7()1( )-29()8()-6()]TJ
3.7644 0 Td
[()1()]TJ
1.0204 0 Td
[()1()10()11()-5()1()2()-3()-4()]TJ
3.9344 0 Td
[()-1()11( )13()]TJ
2.024 0 Td
[()6()2()-9()-9()]TJ
2.4944 0 Td
[(=,1)]TJ
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[(\n)-6()8()19()6()2()2(\n)]TJ
3.3902 0 Td
[()]TJ
1.1055 0 Td
[(E)]TJ
0.7937 0 Td
[(')]TJ
1.0431 0 Td
[()2()8()19()6()2()]TJ
3.8891 0 Td
[()1()]TJ
0.83 0.64 0.02 0 k
1.0205 0 Td
[(5)17()1()]TJ
1.4627 0 Td
[(1)]TJ
0 g
[(")]TJ
1.8481 0 Td
[(\n)5()1()-6()7()2(\n)5()-5()1()8()]TJ
4.371 0 Td
[()-4()3()18()]TJ
1.7915 0 Td
[()-4()2()3(\n)]TJ
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[()7()]TJ
2.0466 0 Td
[()11( )13()11()-11()-5()2()]TJ
2.8289 0 Td
[()3(\n)]TJ
0.8447 0 Td
[( )13()1()11( )13()2(\n)-7()1()19()-6()18()-5()7()8()]TJ
5.8053 0 Td
[()11()]TJ
1.0148 0 Td
[()4()11( )23(.)]TJ
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[()3()-4()]TJ
1.7177 0 Td
[()4()11(.)3()-4()1()1()-5()3()8()19()]TJ
6.2079 0 Td
[()19()1()3()8()]TJ
3.0671 0 Td
[()11(A,)]TJ
1.9105 0 Td
[()8()4()]TJ
1.7178 0 Td
[()4()11()]TJ
1.5647 0 Td
[(\n)5()-9()-6()1()-11()2()]TJ
3.1691 0 Td
[()6()]TJ
1.0261 0 Td
[()-4()4()]TJ
1.4684 0 Td
[(1)]TJ
1.6951 0 Td
[()2()2( )13()-9()1()23()-3()1( )13()11()2()4()1()19()-1(%)]TJ
ET
Q
q
1 j
1 J
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11.9999 0 0 11.9999 200.0125 334.9984 cm
BT
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1 TL
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(and)Tj
1.8756 0 Td
(viability)Tj
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Q
q
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BT
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1 TL
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ET
Q
q
1 j
1 J
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11.9999 0 0 11.9999 380.1826 334.9984 cm
BT
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(CD38)Tj
ET
Q
q
1 j
1 J
0 w
8.9997 0 0 7.999 410.6267 340.3275 cm
BT
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1 TL
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(high)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 430.1291 334.9984 cm
BT
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(with)Tj
1.989 0 Td
(different)Tj
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BT
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[(/)1()4()]TJ
1.7801 0 Td
[( )13()5()-2()18()-5()2()11()8(\n)5()2()12()]TJ
4.9776 0 Td
[()-9()1()-2(\r)8()-6()1()]TJ
3.4923 0 Td
[()7()]TJ
2.0466 0 Td
[()2()-9()8()5()3(\n)]TJ
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[()8()4()]TJ
1.7234 0 Td
[()1()2()19()1()4()11()6()4()1()4()11()-2()-1()11()2()]TJ
8.1468 0 Td
[()4()11( )-4()3()-4()]TJ
3.1237 0 Td
[()11( )13()1()7()1()2()12()6()11( )7(\n)]TJ
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[(,:&')]TJ
ET
Q
q
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1 J
0 w
7.4999 0 0 6.6659 551.7921 308.4661 cm
BT
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1 TL
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[(>.)]TJ
ET
Q
q
1 j
1 J
0 w
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BT
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1 TL
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[(,:&3)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 223.4834 295.4267 cm
BT
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[()2()1()-6()]TJ
ET
Q
q
1 j
1 J
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BT
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[()-11( )2()-6()-5()2()11()]TJ
3.685 0 Td
[(\r)1()1(\n)]TJ
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[()-7()1( )-10()-4()4()1( )]TJ
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[()1(\n)5(\n)-7()2(\n)5(\n)-7()-6()]TJ
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[()15()]TJ
1.1792 0 Td
[()-1()6()2()11()23()]TJ
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[()1(\n)5(\n)-6()18()1(\n)]TJ
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[()3(\n)2()1()8()]TJ
2.3698 0 Td
[()11()1( )-4()1()-11()2()-6()]TJ
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[()11( )13()1()7()1()2()12()6()11( )]TJ
4.4503 0 Td
[(\n)5()5()1(\n)-7()1(\n)]TJ
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[()-11( )13()11()]TJ
2.1883 0 Td
[()-1()11()19()-5( )13()6()]TJ
3.101 0 Td
[(1)]TJ
1.6895 0 Td
[()]TJ
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[(E)]TJ
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[(&%)]TJ
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[(,:&')]TJ
ET
Q
q
1 j
1 J
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7.4999 0 0 6.6659 324.8503 282.444 cm
BT
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1 TL
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[(>)]TJ
ET
Q
q
1 j
1 J
0 w
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BT
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1 TL
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[(,:&3)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 352.6299 282.444 cm
BT
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1 TL
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[()2()1()-6()]TJ
ET
Q
q
1 j
1 J
0 w
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BT
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[(,:';)-5()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 402.5196 282.444 cm
BT
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1 TL
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[(>)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 408.9826 278.022 cm
BT
/F7 1 Tf
1 TL
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[()-1()5()-5()3(\n)]TJ
1.9218 0 Td
[(4A)49(.)1()2( )-4()2()6()4()-6()]TJ
6.8938 0 Td
[()8()4()]TJ
1.7178 0 Td
[(,:&')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 537.7889 282.444 cm
BT
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1 TL
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[(>.)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 264.9826 cm
BT
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1 TL
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[(,:&3)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 223.4834 269.4614 cm
BT
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1 TL
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[()2()1()-6()]TJ
ET
Q
q
1 j
1 J
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10 0 0 10 236.8062 264.9826 cm
BT
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1 TL
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[(,:';)-5()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 273.3165 269.4614 cm
BT
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1 TL
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[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 277.6251 264.9826 cm
BT
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1 TL
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[()-1()5()-5()3(\n)]TJ
1.9218 0 Td
[(,A2DA)49(.)1()2( )-4()2()6()4()-6(")]TJ
9.394 0 Td
[(\r)8()1( )13()]TJ
2.0976 0 Td
[(\n)-7()11( )-10()6()-6()]TJ
2.6872 0 Td
[()1()19()6()]TJ
1.8255 0 Td
[()8()11()1( )]TJ
1.8992 0 Td
[()-9()11()11()-5()-2()18()-5()2()11()8(\n)]TJ
4.9436 0 Td
[()2()1()4()11()6()-6()]TJ
-32.5301 -1.2982 Td
[(:)-19(,5)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 219.0614 256.422 cm
BT
/F7 1 Tf
1 TL
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[()2()15(\r)]TJ
ET
Q
q
1 j
1 J
0 w
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BT
/F7 1 Tf
1 TL
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[(")]TJ
0.4422 0 Td
[(:)-19(,5)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 253.2472 256.422 cm
BT
/F7 1 Tf
1 TL
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[()1()19()]TJ
ET
Q
q
1 j
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