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Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites

Petersen, Ole Holger, Courjaret, Raphael and Machaca, Khaled 2017. Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites. The Journal of Physiology 595 (10) , pp. 2999-3014. 10.1113/JP272772

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Abstract

Ca2+ signaling is perhaps the most universal and versatile mechanism regulating a wide range of cellular processes. Because of the many different calcium-binding proteins distributed throughout cells, signaling precision requires localized rises in the cytosolic Ca2+ concentration. In electrically non-excitable cells, for example epithelial cells, this is achieved by primary release of Ca2+ from the endoplasmic reticulum via Ca2+ release channels placed close to the physiological target. Because any rise in the cytosolic Ca2+ concentration activates Ca2+ extrusion, and in order for cells not to run out of Ca2+, there is a need for compensatory Ca2+ uptake from the extracellular fluid. This Ca2+ uptake occurs through a process known as store-operated Ca2+ entry. Ideally Ca2+ entering the cell should not diffuse to the target site through the cytosol, as this would potentially activate undesirable processes. Ca2+ tunneling through the lumen of the endoplasmic reticulum is a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites, and this process has been described in considerable detail in pancreatic acinar cells and oocytes. Here we review the most important evidence and present a generalized concept.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: The Physiological Society
ISSN: 0022-3751
Funders: MRC
Date of First Compliant Deposit: 24 February 2017
Date of Acceptance: 5 January 2017
Last Modified: 29 Apr 2018 07:39
URI: http://orca.cf.ac.uk/id/eprint/98536

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