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Combustion-derived nanoparticles: mechanisms of pulmonary toxicity

Berube, Kelly Ann, Balharry, Dominique, Sexton, Keith John, Koshy, Lata and Jones, Timothy Peter 2007. Combustion-derived nanoparticles: mechanisms of pulmonary toxicity. Clinical and Experimental Pharmacology and Physiology 34 (10) , pp. 1044-1050. 10.1111/j.1440-1681.2007.04733.x

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Abstract

1. The general term ‘nanoparticle’ (NP) is used to define any particle less than 100 nm in at least one dimension and NPs are generally classified as natural, anthropogenic or engineered in origin. Anthropogenic, also referred to as ‘ultrafine’ particles (UFPs), are predominately combustion derived and are characterized by having an equivalent spherical diameter less than 100 nm. 2. These particles, considered to be ‘combustion-derived nanoparticles’ (CDNPs), are of toxicological interest given their nanosized dimensions, with properties not displayed by their macroscopic counterparts. 3. The pulmonary deposition efficiency of inhaled UFPs, along with their large surface areas and bound transition metals, is considered important in driving the emerging health effects linked to respiratory toxicity. 4. The toxicology of CDNPs is currently used to predict the health outcomes in humans following exposure to manufactured NPs. Their similar physicochemistry would suggest similar adverse health effects (i.e. pulmonary (and perhaps cardiac) toxicity). As such, it is essential to fully understand CDNP nanotoxicology in order to minimize occupational and environmental exposure. Key words: carbon black, combustion-derived particles, diesel exhaust, fly ash, nanoparticles, pulmonary toxicity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Earth and Ocean Sciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: carbon black; combustion-derived particles; diesel exhaust; fly ash; nanoparticles; pulmonary toxicity
Publisher: Wiley
ISSN: 1440-1681
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 30 May 2007
Last Modified: 03 Nov 2017 10:27
URI: http://orca.cf.ac.uk/id/eprint/9899

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