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Altered apolipoprotein C expression in association with cognition impairments and hippocampus volume in schizophrenia and bipolar disorder

Knöchel, Christian, Kniep, Jonathan, Cooper, Jason D., Stäblein, Michael, Wenzler, Sofia, Sarlon, Jan, Prvulovic, David, Linden, David E. J., Bahn, Sabine, Stocki, Pawel, Ozcan, Sureyya, Alves, Gilberto, Carvalho, Andre F., Reif, Andreas and Oertel-Knöchel, Viola 2017. Altered apolipoprotein C expression in association with cognition impairments and hippocampus volume in schizophrenia and bipolar disorder. European Archives of Psychiatry and Clinical Neuroscience 267 (3) , pp. 199-212. 10.1007/s00406-016-0724-3

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Abstract

Proteomic analyses facilitate the interpretation of molecular biomarker probes which are very helpful in diagnosing schizophrenia. In the current study, we attempt to test whether potential differences in plasma protein expressions in schizophrenia (SZ) and bipolar disorder (BD) are associated with cognitive deficits and their underlying brain structures. 42 plasma proteins of 29 SZ patients, 25 BD patients and 93 non-clinical controls were quantified and analysed using multiple reaction monitoring (MRM) based triple quadrupole mass spectrometry approach. We also computed group comparisons of protein expressions between patients and controls, and between SZ and BD patients, as well. Potential associations of protein levels with cognitive functioning (psychomotor speed, executive functioning, crystallized intelligence) as well as underlying brain volume in the hippocampus were explored, using bivariate correlation analyses. The main finding of this study was that apolipoprotein (ApoC) expression differed between patients and controls; and that these alterations in both disease groups were putatively related to cognitive impairments as well as to hippocampus volumes. However, none of the protein level differences were related to clinical symptom severity. In summary, altered apolipoprotein expression in BD and SZ was linked to cognitive decline and underlying morphological changes in both disorders. Our results suggest that the detection of molecular patterns in association with cognitive performance and its underlying brain morphology is of great importance for understanding of the pathological mechanisms of SZ and BD, as well as for supporting the diagnosis and treatment of both disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Psychology
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: APOC, MRM, SMRT, psychosis spectrum, bipolar, schizophrenia, proteomics
Publisher: Springer
ISSN: 0940-1334
Date of First Compliant Deposit: 30 March 2017
Date of Acceptance: 7 August 2016
Last Modified: 06 Sep 2017 13:12
URI: http://orca.cf.ac.uk/id/eprint/99496

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