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The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection.

Howard, Jennifer, Loizon, Séverine, Tyler, Christopher J., Duluc, Dorothée, Moser, Bernhard, Mechain, Matthieu, Duvignaud, Alexandre, Malvy, Denis, Troye-Blomberg, Marita, Moreau, Jean-Francois, Eberl, Matthias, Mercereau-Puijalon, Odile, Déchanet-Merville, Julie, Behr, Charlotte and Mamani-Matsuda, Maria 2017. The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection. Journal of Infectious Diseases 215 (10) , pp. 1569-1579. 10.1093/infdis/jix149

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Abstract

During Plasmodium falciparum infections, erythrocyte-stage parasites inhibit dendritic cell maturation and function; compromising development of effective anti-malarial adaptive immunity. Human Vγ9Vδ2 T-cells can act in vitro as APCs and induce αβ T-cell activation. However, the relevance of this activity in pathophysiological contexts in vivo has remained elusive. Since Vγ9Vδ2 T-cells are activated during the early immune response against P.falciparum infection, we investigated whether they could contribute to the instruction of adaptive immune responses toward malaria parasites. In P.falciparum-infected patients,Vγ9Vδ2 T-cells presented an increased surface expression of APC-associated markers HLA-DR and CD86. In response to infected red blood cells in vitro, Vγ9Vδ2 T-cells readily up-regulated surface expression of HLA-DR, HLA-ABC, CD40, CD80, CD83 and CD86, induced naive αβ T-cell responses, and cross-presented soluble prototypical protein to antigen-specific CD8+ T-cells. Our findings indicate that P. falciparum parasites induce genuine APC properties in Vγ9Vδ2 T-cells and qualify this subset as an alternative professional APC in malaria patients, which could be harnessed for therapeutic interventions and vaccine design.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Publisher: Oxford University Press
ISSN: 0022-1899
Date of First Compliant Deposit: 30 March 2017
Date of Acceptance: 17 March 2017
Last Modified: 24 Nov 2020 21:58
URI: http://orca.cf.ac.uk/id/eprint/99539

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