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Effects of peripapillary scleral stiffening on the deformation of the lamina cribrosa

Coudrillier, Baptiste, Campbell, Ian C., Read, A. Thomas, Geraldes, Diogo M., Vo, Nghia T., Feola, Andrew, Mulvihill, John, Albon, Julie, Abel, Richard L. and Ethier, C. Ross 2016. Effects of peripapillary scleral stiffening on the deformation of the lamina cribrosa. Investigative Ophthalmology & Visual Science 57 (6) , pp. 2666-2677. 10.1167/iovs.15-18193

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Abstract

Purpose: Scleral stiffening has been proposed as a treatment for glaucoma to protect the lamina cribrosa (LC) from excessive intraocular pressure–induced deformation. Here we experimentally evaluated the effects of moderate stiffening of the peripapillary sclera on the deformation of the LC. Methods: An annular sponge, saturated with 1.25% glutaraldehyde, was applied to the external surface of the peripapillary sclera for 5 minutes to stiffen the sclera. Tissue deformation was quantified in two groups of porcine eyes, using digital image correlation (DIC) or computed tomography imaging and digital volume correlation (DVC). In group A (n = 14), eyes were subjected to inflation testing before and after scleral stiffening. Digital image correlation was used to measure scleral deformation and quantify the magnitude of scleral stiffening. In group B (n = 5), the optic nerve head region was imaged using synchrotron radiation phase-contrast microcomputed tomography (PC μCT) at an isotropic spatial resolution of 3.2 μm. Digital volume correlation was used to compute the full-field three-dimensional deformation within the LC and evaluate the effects of peripapillary scleral cross-linking on LC biomechanics. Results: On average, scleral treatment with glutaraldehyde caused a 34 ± 14% stiffening of the peripapillary sclera measured at 17 mm Hg and a 47 ± 12% decrease in the maximum tensile strain in the LC measured at 15 mm Hg. The reduction in LC strains was not due to cross-linking of the LC. Conclusions: Peripapillary scleral stiffening is effective at reducing the magnitude of biomechanical strains within the LC. Its potential and future utilization in glaucoma axonal neuroprotection requires further investigation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: biomechanics, phase contrast microcomputed tomography, digital image correlation, digital volume correlation
Additional Information: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
Publisher: Association for Research in Vision and Ophthalmology
ISSN: 1552-5783
Date of First Compliant Deposit: 30 March 2017
Date of Acceptance: 8 April 2016
Last Modified: 15 Jul 2019 15:55
URI: http://orca.cf.ac.uk/id/eprint/99550

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