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Sleep loss as a trigger of mood episodes in bipolar disorder: individual differences based on diagnostic subtype and gender

Swaden Lewis, Katie J., Gordon-Smith, Katherine, Forty, Elizabeth, Di Florio, Arianna, Craddock, Nicholas, Jones, Lisa and Jones, Ian 2017. Sleep loss as a trigger of mood episodes in bipolar disorder: individual differences based on diagnostic subtype and gender. The British Journal of Psychiatry 211 (3) , pp. 169-174. 10.1192/bjp.bp.117.202259

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Abstract

Background: Sleep loss may trigger mood episodes in people with bipolar disorder (BD) but individual differences could influence vulnerability to this trigger. Aims: To determine whether bipolar subtype (BD-I or BD-II) and gender were associated with vulnerability to the sleep loss trigger. Method: During a semi-structured interview, 3140 individuals (68% female) with BD (66% BD-I) reported whether sleep loss had triggered episodes of high or low mood. DSM-IV diagnosis of bipolar subtype was derived from case note and interview data. Results: Sleep loss triggering episodes of high mood was associated with female gender (OR = 1.43, 95% CI 1.17-1.75, P <.001) and BD-I subtype (OR = 2.81, 95% CI 2.26-3.50, P <.001). Analyses on sleep loss triggering low mood were not significant following adjustment for confounders. Conclusions: Gender and bipolar subtype may increase vulnerability to high mood following sleep deprivation. This should be considered in situations where patients encounter sleep disruption, such as shift-work and international travel.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: The Royal College of Psychiatrists
ISSN: 1472-1465
Last Modified: 27 Jun 2018 21:27
URI: http://orca.cf.ac.uk/id/eprint/99949

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