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Are We Eating Our Way to Prostate Cancer - A Hypothesis Based on the Evolution, Bioaccumulation, and Interspecific Transfer of miR-150

Vaidyanathan, Venkatesh, Krishnamoorthy, Vetrivhel, Karunasinghe, Nishi, Jabed, Anower, Pallati, Radha, Kao, Chi, Wang, Alice, Marlow, Gareth and Ferguson, Lynnette 2016. Are We Eating Our Way to Prostate Cancer - A Hypothesis Based on the Evolution, Bioaccumulation, and Interspecific Transfer of miR-150. Non-Coding RNA 2 (2) , 2. 10.3390/ncrna2020002

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Abstract

MicroRNAs (miRNAs) are well established epigenetic modifiers. There is a lot of work being done to identify the evolutionary transfer of miRNAs both at intra- and interspecific levels. In this hypothesis-driven review, we have suggested a possible reason as to why miR-150 can be a promising diagnostic biomarker for prostate cancer using theories of evolution, bio-accumulation, and interspecific transfer of miRNAs.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Uncontrolled Keywords: miR-150; evolution; nutrigenomics; prostate cancer; bioaccumulation
Additional Information: Correction published as Non-Coding RNA 2016, 2(2), 6; doi:10.3390/ncrna2020006: The authors wish to make the following correction to this paper [1]. Reference 28 has been renumbered to 29, and the following affirmation in the original text: “Dezhong et al. have demonstrated that miR-150 was overexpressed in PCa cells at both the mRNA and protein levels” has been substituted by: “Waltering et al., 2011, reported that miR-150* along with three other miRNAs, namely, miR-10a, miR-141, and miR-1225-5p, among 17 miRNAs, expressed to have >1.5- fold changes at the expression levels in PCa cells and in a minimum of two intact-castration xenograft pair. It has been shown that miR-150 was overexpressed in PCa cells.” Thereby, we include the research done by another group—Waltering et al., 2011—who also found interesting results working on PCa cell-lines and xenografts and the effect of miRNAs (reference no. 31 in the edited version). References 29 and 30 were initially cited unintentionally on page 2 of the article. These references have been deleted from page number 2 and renumbered to 38 and 39 on page 3.
Publisher: MDPI
ISSN: 2311-553X
Date of First Compliant Deposit: 19 April 2017
Date of Acceptance: 15 April 2016
Last Modified: 09 Jun 2020 01:33
URI: http://orca.cf.ac.uk/id/eprint/99973

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