eprintid: 84361 rev_number: 18 eprint_status: archive userid: 913 dir: disk0/00/08/43/61 datestamp: 2016-01-12 09:56:42 lastmod: 2019-06-28 17:18:45 status_changed: 2016-01-12 09:56:42 type: article metadata_visibility: show sword_depositor: 4910 creators_name: Buffet-Bataillon, Sylvie creators_name: Tattevin, Pierre creators_name: Maillard, Jean-Yves creators_name: Bonnaure-Mallet, Martine creators_name: Jolivet-Gougeon, Anne creators_id: MaillardJ@cardiff.ac.uk creators_uniqueid: A040268G title: Efflux pump induction by quaternary ammonium compounds and fluoroquinolone resistance in bacteria ispublished: pub subjects: RM divisions: PHRMY full_text_status: public abstract: Biocides, primarily those containing quaternary ammonium compounds (QAC), are heavily used in hospital environments and various industries (e.g., food, water, cosmetic). To date, little attention has been paid to potential implications of QAC use in the emergence of antibiotic resistance, especially fluoroquinolone-resistant bacteria in patients and in the environment. QAC-induced overexpression of efflux pumps can lead to: cross resistance with fluoroquinolones mediated by multidrug efflux pumps; stress response facilitating mutation in the Quinolone Resistance Determining Region; and biofilm formation increasing the risk of transfer of mobile genetic elements carrying fluoroquinolone or QAC resistance determinants. By following the European Biocidal Product Regulation, manufacturers of QAC are required to ensure that their QAC-based biocidal products are safe and will not contribute to emerging bacterial resistance. date: 2016-01-01 date_type: published publication: Future Microbiology volume: 11 number: 1 publisher: Future Medicine pagerange: 81-92 id_number: 10.2217/fmb.15.131 refereed: TRUE issn: 1746-0913 official_url: http://dx.doi.org/10.2217/fmb.15.131 scopus_impact: 28 scopus_cluster: 84952684984 scopus_datestamp: 2019-06-21 21:03:49 dates_date: 2015-12-17 dates_date: 2016-01-01 dates_date_type: published_online dates_date_type: published hoa_compliant: 501 hoa_emb_len: 12 hoa_ref_pan: AB hoa_date_acc: 2015-10-21 hoa_date_pub: 2015-12-17 hoa_date_fcd: 2016-03-30 hoa_date_foa: 2017-01-01 hoa_version_fcd: AM hoa_exclude: FALSE cardiff_browse_id: A040268G coauthors: 4 coversheet: TRUE date_of_acceptance: 2015-10-21 citation: Buffet-Bataillon, Sylvie, Tattevin, Pierre, Maillard, Jean-Yves , Bonnaure-Mallet, Martine and Jolivet-Gougeon, Anne 2016. Efflux pump induction by quaternary ammonium compounds and fluoroquinolone resistance in bacteria. Future Microbiology 11 (1) , pp. 81-92. 10.2217/fmb.15.131 file document_url: http://orca.cf.ac.uk/84361/3/Efflux%20pump%20induction%20by%20Quaternary%20Ammonium%20Compounds%20%28QAC%29%20and%20fluoroquinolone-resistance%20in%20bacteria.pdf