Reduced intrinsic visual cortical connectivity is associated with impaired perceptual closure in schizophrenia

van de Ven, Vincent, Rotarska Jagiela, Anna, Oertel-Knöchel, Viola and Linden, David Edmund Johannes ORCID: https://orcid.org/0000-0002-5638-9292 2017. Reduced intrinsic visual cortical connectivity is associated with impaired perceptual closure in schizophrenia. NeuroImage: Clinical 15 , pp. 45-52. 10.1016/j.nicl.2017.04.012

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Abstract

Sensory perceptual processing deficits, such as impaired visual object identification and perceptual closure, have been reported in schizophrenia. These perceptual impairments may be associated with neural deficits in visual association areas, including lateral occipital cortex and inferior temporal areas. However, it remains unknown if such deficits can be found in the intrinsic architecture of the visual system. In the current study, we measured perceptual closure performance and resting-state functional connectivity using functional magnetic resonance imaging (FMRI) in 16 schizophrenia patients and 16 matched healthy controls. We estimated intrinsic functional connectivity using self-organized grouping spatial ICA, which clusters component maps in the subject space according to spatial similarity. Patients performed worse than controls in the perceptual closure task. This impaired closure performance of patients was correlated with increased severity of psychotic symptoms. We also found that intrinsic connectivity of the visual processing system was diminished in patients compared to controls. Lower perceptual closure performance was correlated to lower visual cortical intrinsic connectivity overall. We suggest that schizophrenia is associated with impaired intrinsic connectivity of the visual system, and that it is a potential mechanism leading to impaired visual object perception. These findings contribute to increasing evidence for impairments of higher visual functions in schizophrenia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI) Psychology
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Schizophrenia; Visual processing; FMRI; Resting state; Perceptual closure
Publisher:	Elsevier
ISSN:	2213-1582
Date of First Compliant Deposit:	22 May 2017
Date of Acceptance:	15 April 2017
Last Modified:	05 May 2023 13:57
URI:	https://orca.cardiff.ac.uk/id/eprint/100744

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