Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Toxin-antitoxin systems and their role in disseminating and maintaining antimicrobial resistance

Yang, Qiue and Walsh, Timothy ORCID: https://orcid.org/0000-0003-4315-4096 2017. Toxin-antitoxin systems and their role in disseminating and maintaining antimicrobial resistance. FEMS Microbiology Reviews 41 (3) , pp. 343-353. 10.1093/femsre/fux006

[thumbnail of fux006pub.pdf]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

Toxin–antitoxin systems (TAs) are ubiquitous among bacteria and play a crucial role in the dissemination and evolution of antibiotic resistance, such as maintaining multi-resistant plasmids and inducing persistence formation. Generally, activities of the toxins are neutralised by their conjugate antitoxins. In contrast, antitoxins are more liable to degrade under specific conditions such as stress, and free active toxins interfere with essential cellular processes including replication, translation and cell-wall synthesis. TAs have also been shown to be responsible for plasmid maintenance, stress management, bacterial persistence and biofilm formation. We discuss here the recent findings of these multifaceted TAs (type I–VI) and in particular examine the role of TAs in augmenting the dissemination and maintenance of multi-drug resistance in bacteria.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology
R Medicine > R Medicine (General)
Uncontrolled Keywords: toxin–antitoxins, addictive systems, antimicrobial resistance, persistence
Publisher: Wiley-Blackwell
ISSN: 0168-6445
Funders: MRC
Date of First Compliant Deposit: 5 June 2017
Date of Acceptance: 11 February 2017
Last Modified: 14 May 2023 09:46
URI: https://orca.cardiff.ac.uk/id/eprint/101153

Citation Data

Cited 8 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics