Fat accumulates preferentially in the right rather than the left liver lobe in non-diabetic subjects

Hua, Bian, Hakkarainen, Antti, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Lundbom, Nina and Yki-Järvinen, Hannele 2018. Fat accumulates preferentially in the right rather than the left liver lobe in non-diabetic subjects. Digestive and Liver Disease 50 (2) , pp. 168-174. 10.1016/j.dld.2017.08.030

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Abstract

Aims To examine the distribution of liver fat (LFAT) in non-diabetic subjects and test whether the fat in the right as compared to the left lobe correlates better with components of the metabolic syndrome or not. Methods In this cross sectional study, we determined LFAT by 1H-MRS in the right lobe (LFAT%MRS), and by MRI (LFAT%MRI) in four regions of interest (ROIs 1–4, two in the right and two in the left lobe) in 97 non-diabetic subjects (age range 22–74 years, BMI 18–41 kg/m2) and compared the accuracy of LFATMRI in the different ROIs in diagnosing non-alcoholic fatty liver disease (NAFLD) using areas under the receiver operator characteristic (AUROC) curves. Results 38% of the subjects had NAFLD (LFAT%MRS). LFAT%MRI was significantly higher in the right (5.7 ± 0.5%) than the left (5.1 ± 0.4%) lobe (p < 0.02). The AUROC for LFAT%MRI in the right lobe for diagnosing NAFLD was significantly better than that in the left lobe. The relationships between several metabolic parameters and LFAT%MRI in the left lobe were significantly worse than those for LFAT%MRS while there was no difference between LFAT%MRS and right lobe ROIs. Conclusions Liver right lobe contains more fat and correlates better with components of the metabolic syndrome than the left in non-diabetic subjects.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Publisher:	WB Saunders
ISSN:	1590-8658
Date of First Compliant Deposit:	6 October 2017
Date of Acceptance:	14 August 2017
Last Modified:	08 Nov 2023 04:12
URI:	https://orca.cardiff.ac.uk/id/eprint/105257

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