Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Orbitofrontal cortex response to angry faces in men with histories of suicide attempts

Jollant, Fabrice, Lawrence, Natalia Sophie, Giampietro, Vincent, Brammer, Michael J., Fullana, Miguel A,, Drapier, Dominique, Courtet, Phillipe and Phillips, Mary Louise 2008. Orbitofrontal cortex response to angry faces in men with histories of suicide attempts. American Journal of Psychiatry 165 (6) , pp. 740-748. 10.1176/appi.ajp.2008.07081239

Full text not available from this repository.

Abstract

Objective: The authors sought to elucidate the functional neural basis of the neurobiological abnormalities underlying the vulnerability to suicidal behavior. Method: Event-related functional MRI was used to measure neural activity in response to angry and happy versus neutral faces. Thirteen currently euthymic men with a history of major depressive disorder and suicidal behavior were compared with 14 currently euthymic men with a history of major depressive disorder but not of suicidal acts (affective comparison subjects) and 16 healthy male comparison subjects. Results: Relative to affective comparison subjects, suicide attempters showed greater activity in the right lateral orbitofrontal cortex (Brodmann’s area 47) and decreased activity in the right superior frontal gyrus (area 6) in response to prototypical angry versus neutral faces, greater activity in the right anterior cingulate gyrus (area 32 extending to area 10) to mild happy versus neutral faces, and greater activity in the right cerebellum to mild angry versus neutral faces. However, activation in these frontal regions did not differ between healthy individuals and either patient group. Relative to healthy comparison subjects, both patient groups showed reduced activity in the right cerebellum to neutral faces and to mild happy versus neutral faces. Conclusions: Suicide attempters were distinguished from nonsuicidal patients by responses to angry and happy faces that may suggest increased sensitivity to others’ disapproval, higher propensity to act on negative emotions, and reduced attention to mildly positive stimuli. These patterns of neural activity and cognitive processes may represent vulnerability markers of suicidal behavior in men with a history of depression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: American Psychiatric Association
ISSN: 0002-953X
Last Modified: 10 Oct 2017 14:17
URI: https://orca.cardiff.ac.uk/id/eprint/28654

Citation Data

Cited 183 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item