Impaired visuo-spatial recognition memory but normal object novelty detection and relative familiarity judgements in adult mice expressing the APPswe Alzheimer's disease mutation

Hale, Gemma and Good, Mark Andrew ORCID: https://orcid.org/0000-0002-1824-1203 2005. Impaired visuo-spatial recognition memory but normal object novelty detection and relative familiarity judgements in adult mice expressing the APPswe Alzheimer's disease mutation. Behavioral Neuroscience 119 (4) , pp. 884-891. 10.1037/0735-7044.119.4.884

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Abstract

The present study examined the effects of a human APPswe mutation on object recognition memory in adult Tg2576 mice. The results showed that 14-month old Tg2576 mice were able to detect object novelty as well as control mice, even with delays of up to 24 hr. In addition, transgenic mice showed a normal recency effect and explored the most recently encountered object significantly less than an object encountered earlier in a trial. However, adult Tg2576 mice showed impairments in detecting a change in the relative positions of an array of familiar objects. The results suggest that the formation of representations involving a combination of object identity and spatial information are particularly sensitive to amyloid pathology in adult APPswe mutant mice. (PsycINFO Database Record (c) 2012 APA, all rights reserved)

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	American Psychological Association
ISSN:	0735-7044
Last Modified:	17 Oct 2022 09:28
URI:	https://orca.cardiff.ac.uk/id/eprint/3293

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