Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study

O'Sullivan, M., Summers, P. E., Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049, Jarosz, J. M., Williams, S. C. R. and Markus, H. S. 2001. Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study. Neurology 57 (12) , pp. 2307-2310. 10.1212/WNL.57.12.2307

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Abstract

Ischemic leukoaraiosis is a consistent concomitant of vascular dementia. Conventional MRI provides little information about underlying white matter tract disruption and correlates poorly with cognitive dysfunction. Diffusion tensor MRI may provide better markers of tract integrity. Changes in the normal-appearing white matter were demonstrated in 30 patients with ischemic leukoaraiosis compared with 17 age-matched control subjects. These changes correlated with executive dysfunction assessed by the Wisconsin Card Sorting Test.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	American Academy of Neurology
ISSN:	0028-3878
Last Modified:	21 Oct 2022 09:07
URI:	https://orca.cardiff.ac.uk/id/eprint/35381

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