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The molecular determinants of CD8 co-receptor function

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Laugel, Bruno Frederic, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. The molecular determinants of CD8 co-receptor function. Immunology 137 (2) , pp. 139-148. 10.1111/j.1365-2567.2012.03625.x

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Abstract

CD8+ T cells respond to signals mediated through a specific interaction between the T-cell receptor (TCR) and a composite antigen in the form of an epitopic peptide bound between the polymorphic α1 and α2 helices of an MHC class I (MHCI) molecule. The CD8 glycoprotein ‘co-receives’ antigen by binding to an invariant region of the MHCI molecule and can enhance ligand recognition by up to 1 million-fold. In recent years, a number of structural and biophysical investigations have shed light on the role of the CD8 co-receptor during T-cell antigen recognition. Here, we provide a collated resource for these data, and discuss how the structural and biophysical parameters governing CD8 co-receptor function further our understanding of T-cell cross-reactivity and the productive engagement of low-affinity antigenic ligands.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Uncontrolled Keywords: CD8, co-receptor, biophysics, crystal structure, peptide–major histocompatibility complex, T-cell activation, T-cell receptor
Publisher: Wiley Blackwell
ISSN: 0019-2805
Last Modified: 27 Jul 2023 01:08
URI: https://orca.cardiff.ac.uk/id/eprint/42122

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