Surgery for Parkinson's disease: lack of reliable clinical trial evidence

Stowe, R. L., Wheatley, K., Clarke, C. E., Ives, N. J., Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Williams, A. C., Daniels, J. P. and Gray, R. 2003. Surgery for Parkinson's disease: lack of reliable clinical trial evidence. Journal of Neurology, Neurosurgery & Psychiatry 74 (4) , pp. 519-521. 10.1136/jnnp.74.4.519

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Abstract

There has been a striking resurgence of interest in surgery for Parkinson’s disease (PD) with new targets identified and new procedures developed. This systematic review identified over 500 studies of surgery for PD published since 1990, including over 10 000 patients. However, the authors were unable to assess the value of PD surgery reli- ably because only seven randomised trials were identified including just 196 patients. Studies of surgery for PD have generally been of poor quality with too few patients, too short follow up, inappropriate choice of outcome measures, and lack of control groups. Much larger, randomised, controlled trials are needed to assess the longer term effects of surgery on patient rated quality of life and cost effectiveness.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	BMJ Publishing Group
ISSN:	0022-3050
Last Modified:	24 Oct 2022 11:54
URI:	https://orca.cardiff.ac.uk/id/eprint/49707

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