Concise review: Immune recognition of induced pluripotent stem cells

Boyd, Ashleigh S., Rodrigues, Neil ORCID: https://orcid.org/0000-0002-1925-7733, Lui, Kathy O., Fu, Xuemei and Xu, Yang 2012. Concise review: Immune recognition of induced pluripotent stem cells. Stem Cells 30 (5) , pp. 797-803. 10.1002/stem.1066

Full text not available from this repository.

Abstract

Autologous-induced pluripotent stem cells (iPSCs) may eventually be used in cell replacement therapies to treat a wide range of diseases and have been touted as a solution to the vexing problem of immune rejection in this context. Emerging evidence suggests, however, that ostensibly histocompatible iPSCs may be rejected following transplantation. Here, we review the mechanisms that contribute to immunogenicity in iPSCs and forward approaches to permit their acceptance in potential cell replacement therapies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Subjects:	Q Science > QH Natural history > QH301 Biology
Uncontrolled Keywords:	Stem cells; Embryonic stem cells; Induced pluripotent stem cells; Cell replacement therapy; Immunogenicity; Transplantation; Tolerance; Rejection; Regenerative medicine
Publisher:	AlphaMed Press
ISSN:	1066-5099
Last Modified:	22 Jun 2023 10:01
URI:	https://orca.cardiff.ac.uk/id/eprint/51133

Citation Data

Cited 52 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item