Cyclin D2 is a GATA4 cofactor in cardiogenesis

Yamak, Abir, Latinkic, Branko V. ORCID: https://orcid.org/0000-0003-4952-123X, Dali, Rola, Temsah, Rana and Nemer, Mona 2014. Cyclin D2 is a GATA4 cofactor in cardiogenesis. Proceedings of the National Academy of Sciences 111 (4) , pp. 1415-1420. 10.1073/pnas.1312993111

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Abstract

Cyclin D2 is a cell cycle regulator with spatially restricted expression. Loss and gain of function in animal models also revealed a role in cell differentiation, but the mechanisms underlying this are incompletely understood. The cardiogenic transcription factor GATA4 is an upstream regulator of cyclin D2. We show that GATA4 and cyclinD2 are part of a forward reinforcing loop in which cyclin D2 feeds back to enhance GATA4 activity through direct interaction. Mutations in GATA4 that abrogate cyclin D2 interactions are associated with human congenital heart disease. The results unravel a unique transcriptional role of cyclin D2 that may underlie its cell specificity. The finding that cyclin D2 is a cardiogenic GATA4 cofactor may be exploitable therapeutically for heart repair.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH426 Genetics
Publisher:	National Academy of Sciences
ISSN:	0027-8424
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	13 December 2013
Last Modified:	23 May 2023 16:05
URI:	https://orca.cardiff.ac.uk/id/eprint/56947

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