Emerging roles of the extracellular calcium-sensing receptor in nutrient sensing: control of taste modulation and intestinal hormone secretion

Brennan, Sarah C. ORCID: https://orcid.org/0000-0002-8719-4367, Davies, Thomas S., Schepelmann, Martin ORCID: https://orcid.org/0000-0002-7017-5426 and Riccardi, Daniela ORCID: https://orcid.org/0000-0002-7322-3163 2014. Emerging roles of the extracellular calcium-sensing receptor in nutrient sensing: control of taste modulation and intestinal hormone secretion. British Journal of Nutrition 111 (S1) , S16-S22. 10.1017/S0007114513002250

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Abstract

The extracellular Ca-sensing receptor (CaSR) is a sensor for a number of key nutrients within the body, including Ca ions (Ca2+) and l-amino acids. The CaSR is expressed in a number of specialised cells within the gastrointestinal (GI) tract, and much work has been done to examine CaSR's role as a nutrient sensor in this system. This review article examines two emerging roles for the CaSR within the GI tract – as a mediator of kokumi taste modulation in taste cells and as a regulator of dietary hormone release in response to l-amino acids in the intestine.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Pharmacy
Subjects:	Q Science > QR Microbiology
Uncontrolled Keywords:	Calcium-sensing receptor; Nutrient-sensing; Amino acids; Gastrointestinal tract; Taste modulation; Taste receptors
Additional Information:	Published online before print 2 Jan 2014.
Publisher:	Nuitrition Society
ISSN:	0007-1145
Funders:	BBSRC, Marie Curie ITN
Date of First Compliant Deposit:	30 March 2016
Last Modified:	28 Jul 2023 01:42
URI:	https://orca.cardiff.ac.uk/id/eprint/56980

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