Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia

Speight, G., Guy, Carol, Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Asherson, P., McGuffin, P., Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 1997. Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia. American Journal of Medical Genetics 74 (2) , pp. 204-206. 10.1002/(SICI)1096-8628(19970418)74:2<204::AID-AJMG19>3.0.CO;2-M

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Abstract

The hypothesis that expanded trinucleotide repeats contribute to the pathogenesis of schizophrenia and bipolar disorder has been recently supported by three independent studies which have shown that patients with either disorder tend to have larger CAG/CTG repeat expansion detection products than controls. In an attempt to identify the specific expanded CAG/CTG locus or loci which are associated with schizophrenia and bipolar disorder, we determined the repeat size at CAG/CTG loci mapping to candidate regions for psychosis. In this study we report our findings from eight loci which map to chromosome 4. We conclude that these loci are unlikely candidates for CAG/CTG repeat expansion in schizophrenia and bipolar disorder.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Bipolar Disorder / genetics*, Chromosome Mapping, Chromosomes, Human, Pair 4*, Humans, Schizophrenia / genetics*, Trinucleotide Repeats*
Additional Information:	Publication Types Research Support, Non-U.S. Gov't Grant Support Wellcome Trust/United Kingdom Full Text Sources John Wiley & Sons, Inc. Other Literature Sources COS Scholar Universe Medical chromosome 4 - Genetics Home Reference Bipolar Disorder - MedlinePlus Health Information Schizophrenia - MedlinePlus Health Information
Publisher:	Wiley-Liss
ISSN:	0148-7299
Last Modified:	12 Dec 2022 08:55
URI:	https://orca.cardiff.ac.uk/id/eprint/58009

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